Aln cancer breast





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Evolutionary history of metastatic breast cancer reveals minimal seeding from axillary lymph nodes

Siegel, …Lisa A. In the first step, we detected indels in each sample using a minimum cancer sample read depth of 20, a minimum control sample read depth of 15, a minimum number of reads supporting a variant allele in a tumor sample of 4, a maximum number of reads supporting a variant allele in a normal sample of 0, a minimum variant allele frequency of 0. B Heatmap showing genomic alterations in known breast cancer genes in 6 different categories across the patients. Aln cancer breast linear evolution to successive metastatic sites was common, parallel evolution from the primary tumor to multiple distant sites was also evident. For patient 4, six different regions of primary tumors Primary1 to Primary6 and 3 metastatic cancers from uterus relapse 2 Aln cancer breast.

Aln cancer breast
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Nevertheless, every tree was consistent with cancer being initiated in a single cell. For instance, in patient 4, we observed that distinct, spatially separated subclones in the primary tumor were independently seeding different distant organ metastases. We studied subclonal propagation southpark thumbs up the primary cancer to distant metastases in 15 patients, after excluding 5 patients patients 6, 7, 12, 13, and 16 for whom the sequencing data from either the primary cancer or the distant metastasis was missing. In other words, ALN status is very useful for predicting the tumorigenic capability of the primary tumor but does not drive metastasis per se. In this run, we used single nucleotide polymorphism database dbSNP variants, versionand Catalogue of Somatic Mutations in Cancer variants, build 68, as inputs to MuTect.

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1 thoughts on “Aln cancer breast
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